Advances in Immunology, Vol. 44 by Frank J. Dixon (Editor) PDF

By Frank J. Dixon (Editor)

ISBN-10: 0120224445

ISBN-13: 9780120224449

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The J-like sequences in nonrearranging IgGSF members. Shown for comparison are consensus J sequences for the three Ig families. Similarity to the J X consensus is indicated by dots. Gaps inserted to optimize alignment between J elements are indicated with dashes. , 1987), one without a disulfide loop. , 1986). Therefore, although the foreshortened nature of the second homology unit might suggest that it belongs to the H class of sequences, its similarity to the V-like region implies that it should also be classified as V-like.

No matter how diverse a junctional window is, if the rest of the sequence is essentially the same as many of the other members of the V gene family, the overall range of specificities will be severely truncated. Therefore, a diverse germ line repertoire of V gene segments may have more to do with providing this range than in contributing to greater combinatorial numbers. Certainly, from our previous calculations the number of potential receptors would not be much affected relative to actual clones expressed even if the number of V segments is reduced substantially (compare V H and Vp, for example).

1986) and appear to result from small, gene conversion-like events between similar sequences. These events may account for much of the high rate of mutation at some MHC loci, as high as 1OP3/gene/generation in mice (Melvold and Kohn, 1975). , 1983). Interestingly, certain K alleles appear to undergo spontaneous gene conversion-likeevents an order of magnitude more frequently than the D alleles. Thus, position in the multigene family may dictate the frequency of recombination-like events. While miniconversion events will extend diversity between alleles, they will also maintain a higher level of similarity between gene family members in general (a conversion inherently makes the two involved sequences more similar).

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Advances in Immunology, Vol. 44 by Frank J. Dixon (Editor)

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