New PDF release: Advances in Cancer Research

By George F. Vande Woude; George Klein (Eds.)

ISBN-10: 0123747724

ISBN-13: 9780123747723

Advances in melanoma learn offers important info at the interesting and fast-moving box of melanoma research. In this half A volume, outstanding and unique stories offer an summary and synthesis of the newest innovations and findings in relation to Clusterin. Chapters comprise the shifiting stability among CLU varieties in the course of tumor development, uclear CLU and the destiny of the phone, and Oxidative rigidity in malignant development.

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2004) showed identical reaction in human prostate cells when BAPTA AM was utilized to eliminate intracellular calcium. BAPTA AM is a well-known intracellular calcium blocker that enters the cell, is cleaved and trapped irreversibly as charged Ca2þ chelator. , 2005). It is not clear, if intracellular Ca2þ depletion, or Ca2þ influx from the outside elicit cell death. The risk of BAPTA toxicity at higher doses may also be attributed to Ca2þ deprivation from ER as BAPTA can enter this compartment.

J. Clin. Invest. 85, 1477–1486. , et al. (2005). Identification of novel RARbeta2 transcript variants with short 50 -UTRs in normal and cancerous breast epithelial cells. Oncogene 24, 1296–1301. , et al. (2000). Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state. Biochemistry 39, 15953–15960. , et al. (2002a). Mildly acidic pH activates the extracellular molecular chaperone clusterin. J. Biol. Chem. 277, 39532–39540.

Nuclear translocation of a clusterin isoform is associated with induction of anoikis in SV40-immortalized human prostate epithelial cells. Ann. N. Y. Acad. Sci. 1010, 514–519. Caccamo, A. , et al. (2004). Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin. Biochem. J. 382, 157–168. Caccamo, A. , et al. (2005). Ca2þ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells.

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Advances in Cancer Research by George F. Vande Woude; George Klein (Eds.)

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